Gene information
Official symbol APOC3
Official full name apolipoprotein C3
Gene type protein-coding gene
Chromosome11q23.3
Gene familyApolipoproteins
Resources
Entrez Gene 345
HGNC HGNC:610
Ensembl ENSG00000110245
Vega OTTHUMG00000046115
UCSC uc001ppt.2
GO terms: 92 records
GO Description Category LogP Number of genes Detail
GO:0004857 enzyme inhibitor activity GO Molecular Functions -18.4005452 35 More
GO:0005496 steroid binding GO Molecular Functions -8.57765300 12 More
GO:0005543 phospholipid binding GO Molecular Functions -6.61792344 45 More
GO:0005769 early endosome GO Cellular Components -6.25251045 19 More
GO:0006638 neutral lipid metabolic process GO Biological Processes -9.91206723 13 More
GO:0006639 acylglycerol metabolic process GO Biological Processes -9.97063695 13 More
GO:0006641 triglyceride metabolic process GO Biological Processes -9.32996784 11 More
GO:0006869 lipid transport GO Biological Processes -16.6388990 29 More
GO:0008289 lipid binding GO Molecular Functions -15.8223476 88 More
GO:0009895 negative regulation of catabolic process GO Biological Processes -10.3621088 43 More
GO:0010565 regulation of cellular ketone metabolic process GO Biological Processes -15.3155739 32 More
GO:0010876 lipid localization GO Biological Processes -20.1994935 34 More
GO:0010896 regulation of triglyceride catabolic process GO Biological Processes -3.26297857 3 More
GO:0010901 regulation of very-low-density lipoprotein particle remodeling GO Biological Processes -4.49239295 3 More
GO:0015485 cholesterol binding GO Molecular Functions -6.09984616 12 More
GO:0015748 organophosphate ester transport GO Biological Processes -5.98331847 11 More
GO:0015850 organic hydroxy compound transport GO Biological Processes -17.9399475 23 More
GO:0015914 phospholipid transport GO Biological Processes -7.60367088 11 More
GO:0015918 sterol transport GO Biological Processes -16.3959877 17 More
GO:0016042 lipid catabolic process GO Biological Processes -9.62855375 20 More
GO:0019216 regulation of lipid metabolic process GO Biological Processes -24.8423986 38 More
GO:0019217 regulation of fatty acid metabolic process GO Biological Processes -12.5607102 15 More
GO:0019433 triglyceride catabolic process GO Biological Processes -7.04725442 6 More
GO:0030301 cholesterol transport GO Biological Processes -18.3843949 17 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031330 negative regulation of cellular catabolic process GO Biological Processes -6.88355184 32 More
GO:0032368 regulation of lipid transport GO Biological Processes -34.5766289 54 More
GO:0032369 negative regulation of lipid transport GO Biological Processes -16.5715041 21 More
GO:0032371 regulation of sterol transport GO Biological Processes -19.2332049 29 More
GO:0032372 negative regulation of sterol transport GO Biological Processes -11.6691020 14 More
GO:0032374 regulation of cholesterol transport GO Biological Processes -19.2332049 29 More
GO:0032375 negative regulation of cholesterol transport GO Biological Processes -11.6691020 14 More
GO:0032489 regulation of Cdc42 protein signal transduction GO Biological Processes -5.88286021 4 More
GO:0032934 sterol binding GO Molecular Functions -5.20663428 12 More
GO:0032994 protein-lipid complex GO Cellular Components -17.0133835 14 More
GO:0033344 cholesterol efflux GO Biological Processes -10.9607436 9 More
GO:0033700 phospholipid efflux GO Biological Processes -8.63513275 6 More
GO:0034358 plasma lipoprotein particle GO Cellular Components -17.5986271 14 More
GO:0034361 very-low-density lipoprotein particle GO Cellular Components -8.67626191 7 More
GO:0034363 intermediate-density lipoprotein particle GO Cellular Components -5.18367662 3 More
GO:0034364 high-density lipoprotein particle GO Cellular Components -15.5094832 12 More
GO:0034366 spherical high-density lipoprotein particle GO Cellular Components -7.69370672 5 More
GO:0034367 protein-containing complex remodeling GO Biological Processes -22.5554593 16 More
GO:0034368 protein-lipid complex remodeling GO Biological Processes -23.1924108 16 More
GO:0034369 plasma lipoprotein particle remodeling GO Biological Processes -23.1924108 16 More
GO:0034375 high-density lipoprotein particle remodeling GO Biological Processes -13.3517229 9 More
GO:0034377 plasma lipoprotein particle assembly GO Biological Processes -8.18952769 7 More
GO:0034381 plasma lipoprotein particle clearance GO Biological Processes -16.8165221 12 More
GO:0034385 triglyceride-rich plasma lipoprotein particle GO Cellular Components -8.67626191 7 More
GO:0035023 regulation of Rho protein signal transduction GO Biological Processes -3.55619697 12 More
GO:0042157 lipoprotein metabolic process GO Biological Processes -6.61578697 11 More
GO:0042304 regulation of fatty acid biosynthetic process GO Biological Processes -6.97247167 8 More
GO:0042627 chylomicron GO Cellular Components -8.37064445 6 More
GO:0042632 cholesterol homeostasis GO Biological Processes -21.5492593 34 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0043178 alcohol binding GO Molecular Functions -5.93737043 9 More
GO:0043691 reverse cholesterol transport GO Biological Processes -17.1886584 11 More
GO:0044242 cellular lipid catabolic process GO Biological Processes -5.52561510 12 More
GO:0045833 negative regulation of lipid metabolic process GO Biological Processes -7.94928400 20 More
GO:0045922 negative regulation of fatty acid metabolic process GO Biological Processes -4.09043632 8 More
GO:0046461 neutral lipid catabolic process GO Biological Processes -7.3012399 7 More
GO:0046464 acylglycerol catabolic process GO Biological Processes -7.3012399 7 More
GO:0046486 glycerolipid metabolic process GO Biological Processes -5.86759713 18 More
GO:0046503 glycerolipid catabolic process GO Biological Processes -7.85666327 9 More
GO:0046578 regulation of Ras protein signal transduction GO Biological Processes -3.44587232 19 More
GO:0046890 regulation of lipid biosynthetic process GO Biological Processes -16.6841590 23 More
GO:0050994 regulation of lipid catabolic process GO Biological Processes -9.86212956 11 More
GO:0050995 negative regulation of lipid catabolic process GO Biological Processes -4.91348267 5 More
GO:0051004 regulation of lipoprotein lipase activity GO Biological Processes -4.09160195 4 More
GO:0051051 negative regulation of transport GO Biological Processes -46.8709407 107 More
GO:0051129 negative regulation of cellular component organization GO Biological Processes -13.1016989 75 More
GO:0051346 negative regulation of hydrolase activity GO Biological Processes -26.0030636 42 More
GO:0055088 lipid homeostasis GO Biological Processes -20.8046481 43 More
GO:0055090 acylglycerol homeostasis GO Biological Processes -12.4730141 17 More
GO:0055092 sterol homeostasis GO Biological Processes -21.3864243 34 More
GO:0060191 regulation of lipase activity GO Biological Processes -10.2745708 13 More
GO:0060192 negative regulation of lipase activity GO Biological Processes -2.88014031 3 More
GO:0060627 regulation of vesicle-mediated transport GO Biological Processes -25.1756709 46 More
GO:0062012 regulation of small molecule metabolic process GO Biological Processes -26.8746473 69 More
GO:0062014 negative regulation of small molecule metabolic process GO Biological Processes -11.3582124 24 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0065005 protein-lipid complex assembly GO Biological Processes -7.77416886 7 More
GO:0070325 lipoprotein particle receptor binding GO Molecular Functions -8.90426631 8 More
GO:0070328 triglyceride homeostasis GO Biological Processes -12.4730141 17 More
GO:0071825 protein-lipid complex subunit organization GO Biological Processes -20.9970896 17 More
GO:0071827 plasma lipoprotein particle organization GO Biological Processes -21.6197515 17 More
GO:0090207 regulation of triglyceride metabolic process GO Biological Processes -7.43834818 8 More
GO:0097006 regulation of plasma lipoprotein particle levels GO Biological Processes -27.6960426 22 More
GO:1905952 regulation of lipid localization GO Biological Processes -40.6150331 64 More
GO:1905953 negative regulation of lipid localization GO Biological Processes -25.1573575 31 More
GO:1990777 lipoprotein particle GO Cellular Components -17.5986271 14 More
KEGG pathways: 2 records
KEGG Description Category LogP Number of genes Detail
hsa03320 PPAR signaling pathway KEGG Pathway -10.0668076 12 More
hsa04979 Cholesterol metabolism KEGG Pathway -20.0696655 17 More
Drug-Gene interaction
view
Related drugs: 1 record
Drug name Interaction type Source PMID View
ritonavir PharmGKB 15809899 view
Related studies: 7 records
Molecular factor Omics type Application Objective MI type Reference
NM_000040.3:c.[-641C>A;-482C>T;-455T>C;1100C>T;*40G>C;3206C>G] genomics myocardial infarction[diagnosis] myocardial infarction Tobin MD et al. Eur Heart J. 2004
NM_000040.3:c.[*40G>C;-455T>C;-482C>T] genomics myocardial infarction[diagnosis] myocardial infarction Ruiz-Narvaez EA et al. J Lipid Res. 2005
NM_000040.3:c.[*40G>C;-455T>C;-482C>T] genomics acute myocardial infarction[diagnosis] acute myocardial infarction Ruiz-Narvaez EA et al. Am J Clin Nutr. 2008
NM_000040.3:c.*40G>C genomics acute myocardial infarction[diagnosis] acute myocardial infarction Abd El-Aziz TA et al. Mol Cell Biochem. 2011
NM_000040.3:c.*40G>C genomics myocardial infarction[diagnosis] myocardial infarction Sediri Y et al. Eur J Intern Med. 2011
apolipoprotein C-III proteomics myocardial infarction[diagnosis] myocardial infarction Al-Muhtaseb N et al. Ann Saudi Med. 1992
apolipoprotein C-III proteomics fish oil[other] old myocardial infarction Swahn E et al. Clin Drug Investig. 1998
All rights reserved: Soochow University Center for Systems Biology